Synthesis, Characterization, Antimicrobial, Anti-Diabetic, Anti-Inflammatory and Anti-Cancer studies of Schiff Base metal(II) complexes derived from 4-hydroxy-3,5 dimethoxybenzaldehyde and 3-aminoquinoline

Abstract

The new Schiff base ligand (E)-2,6-dimethoxy-4-((quinolin-3-ylimino)methyl )phenol (HL) and its Cu(II), Co(II), Ni(II) and Zn(II) metal complexes were synthesized and characterized by various spectroscopic (UV-vis, IR, NMR), SEM, Mass and magnetic susceptibility measurement. The ligand (HL) was synthesized by condensation of 4-hydroxy-3,5-dimethoxybenzaldehyde and 3-aminoquinoline. On the basis of electronic spectral data and magnetic susceptibility measurement the tetrahedral geometry has been proposed for all the complexes. The ligand and metal complexes have been screened for their antimicrobial activities against bacteria (Staphylococcus aureus, Escherichia coli) and antifungal activity against the fungi (Candida albicans). Further the ligand and its Cu(II) complex was also screened for anticancer activity on human cancer cell lines such as breast (MCF7) by MTT assay method . Interestingly, Cu(II) complex shows better anticancer activity than the free schiffbase ligand . The in vitro anti-inflammatory and anti-diabetic activities of the ligand and Cu(II) complex were studied. The Cu(II) complex show higher inhibition activity than that of the free ligand.