New Mixed Ligand Saccharin Complexes with o-Phenylenediamine Schiff Base and Antioxidant Investigations

Abstract

In this study, four new mixed-ligand saccharin complexes with 2-[[(2-Aminophenyl)imino]methyl]-6-methoxy phenol Schiff base were prepared and characterized with various methods including elemental analysis, FT-IR spectroscopy, UV-vis spectroscopy, NMR spectroscopy, QTOF-LC/MS spectroscopy. All methods confirmed the inclusion of the Schiff base obtained by condensation of o-phenylendiamine and o-vanillin into the metal saccharinates. Besides, DPPH scavenging activities and metal chelating abilities of all complexes were determined and compared to well-known antioxidant standarts (Butylated hydroxyanisole, Butylated hydroxytoluene and α-Tocopherol) along with starting metal saccharinates. According to the results, nickel complex exhibited the best DPPH scavenging activity, while copper complex had the highest ferrous ion chelating ability.