Synthesis and Spectroscopic Investigation of Binding of Novel Thiazolo [2, 3-a] isoquinoline analog with Bovine Serum Albumin

Ranade, Prasanna B; Navale, Dinesh N; Zote, Santosh W; Kulal, Dnyaneshwar K; Vasim Sheikh, Mohamad ; Ramana, M M V

Abstract

A condensation reaction between 1-cyclobutyl-3,4-dihydroisoquinoline and thioglycolic acid was carried out using DCC yields 10b-cyclobutyl-5,6-dihydro-2H-thiazolo [2, 3-a] isoquinolin-3(10bH)-one [CBIQTGA]. The interaction of CBIQTGA with Bovine Serum Albumin (BSA) was studied using UV spectroscopy, spectrofluorimetry and circular dichroism (CD) techniques.


Keyword(s)

DCC, cyclisation, BSA, Fluorescence, Circular Dichroism.


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