Preparation of ultra-porous UPM/PHBV nanofibres using solvent-etching technology and drug-loading efficiency

Jin, Lanming ; Jiang, Gaoming ; Liu, Shuiping

Abstract

In this study, ultra-porous fibres have been produced by partly washing out poly(3-hydroxybutyrateco-3-hydroxyvalerate) (PHBV) from the heat-crosslinked electrospun unsaturated polyester macromonomers/poly(3-hydroxybutyrateco-3-hydroxyvalerate) (UPM/PHBV) fibrous composite using chloroform. Tetracycline hydrochloride has been used as the module drug to test the drug-loading efficiency of porous fibres. Field emission scanning electron microscope images show that the etched UPM/PHBV fibres have lost the original smooth surface. The result demonstrates that the PHBV is successfully washed by chloroform, but most of UPM is remained because of the heat-crosslinking. Furthermore, with the increase of PHBV ratio in composite fibres, the etched fibres show much rougher surface. The drug absorption behavior also varies with the different PHBV ratios.


Keyword(s)

Drug loading efficiency; Electrospinning; Poly(3-hydroxybutyrateco-3-hydroxyvalerate); Solvent etching; Ultra-porous fibres; Nanofibres; Unsaturated polyester macromonomers

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